Chronotherapy using corticosteroids for multiple sclerosis relapses

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Cortical relapses in multiple sclerosis.

BACKGROUND Multiple sclerosis (MS) is a white and grey matter disease of the central nervous system (CNS). It is recognized that cortical damage (i.e. focal lesions and atrophy) plays a role in determining the accumulation of physical and cognitive disability that is observed in patients with progressive MS. To date, an association of cortical lesions with clinical relapses has not been describ...

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Corticosteroids and multiple sclerosis.

It is common practice to employ a short course of corticosteroids to treat acute relapses of multiple sclerosis. Two approaches, high dose intravenous methylpred-nisolone (IVMP) and intramuscular ACTH, have been shown when compared to placebo to shorten the duration of relapses, 1 2 although there is no evidence that the final outcome is changed. Of these, IVMP has become the more popular, bein...

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EFNS guideline on treatment of multiple sclerosis relapses: report of an EFNS task force on treatment of multiple sclerosis relapses.

Relapses, exacerbations or attacks of multiple sclerosis are the dominating feature of relapsing-remitting multiple sclerosis (MS), but are also observed in patients with secondary progressive MS. High-dose methylprednisolone is the routine therapy for relapses at present, but other treatments are also in current use. The objective of the task force was to review the literature on treatment of ...

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ژورنال

عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry

سال: 2007

ISSN: 0022-3050

DOI: 10.1136/jnnp.2006.104000